31-181
Proteínas morfogenéticas óseas (BMPs): Efecto de la proteína osteogénica-1 (OP-l/BMP-7) en la condrogénesis y osteogenesis
BONE MORPHOGENETIC PROTEINS (bmps): EFFECT OF THE OSTEOGENIC PROTEIN-1 (OP-l/BMP-7) ON CHONDROGENESIS AND OSTEOGENESIS
J. L. PERIS, J. PRAT, R. DEJOZ, M. COMIN, C. AT1ENZA, J. S. BARREDA, I. ROGER,C. REIG y P. VERA Instituto de Biomecánica de Valencia (1BV). Valencia Parque Tecnológico. Paterna (Valencia).
Recepción:
06/11/2008
Aceptación:
06/11/2008
Publicación:
06/11/2008
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Resumen (ES)
Nowadays, molecular biology studies have promoted the bone morphogenetic
proteins (BMPs) analysis. These multifunctional proteins are structurally related to transforming
growth factor-6 (TGF-6). Genetic engineering techniques have allowed to sequence some of these
BMPs. It has been characterized the expression and processing of osteogenic protein-1 (OP-1),
a bone morphogenetic protein of the TGF-6 family. The OP-1 shows a high osteogenic and chondrogenic
potential. The aim of this paper is to review some updated advances of the BMPs experimental
applications, particularly OP-1, in relation to Orthopaedic Surgery and Traumatology.
proteins (BMPs) analysis. These multifunctional proteins are structurally related to transforming
growth factor-6 (TGF-6). Genetic engineering techniques have allowed to sequence some of these
BMPs. It has been characterized the expression and processing of osteogenic protein-1 (OP-1),
a bone morphogenetic protein of the TGF-6 family. The OP-1 shows a high osteogenic and chondrogenic
potential. The aim of this paper is to review some updated advances of the BMPs experimental
applications, particularly OP-1, in relation to Orthopaedic Surgery and Traumatology.
Palabras clave (ES):
Proteína
Consolidación
Reparación
Regeneración
Ósea
Morfogenética
BMPsOstegénica-1
OP-1/BMP-7
Condrogénesis
Osteogénesis
Resumen (EN)
Nowadays, molecular biology studies have promoted the bone morphogenetic
proteins (BMPs) analysis. These multifunctional proteins are structurally related to transforming
growth factor-6 (TGF-6). Genetic engineering techniques have allowed to sequence some of these
BMPs. It has been characterized the expression and processing of osteogenic protein-1 (OP-1),
a bone morphogenetic protein of the TGF-6 family. The OP-1 shows a high osteogenic and chondrogenic
potential. The aim of this paper is to review some updated advances of the BMPs experimental
applications, particularly OP-1, in relation to Orthopaedic Surgery and Traumatology.
proteins (BMPs) analysis. These multifunctional proteins are structurally related to transforming
growth factor-6 (TGF-6). Genetic engineering techniques have allowed to sequence some of these
BMPs. It has been characterized the expression and processing of osteogenic protein-1 (OP-1),
a bone morphogenetic protein of the TGF-6 family. The OP-1 shows a high osteogenic and chondrogenic
potential. The aim of this paper is to review some updated advances of the BMPs experimental
applications, particularly OP-1, in relation to Orthopaedic Surgery and Traumatology.
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