30-178
Tratamiento del osteosarcoma localizado de las extremidades*
Treatment of localized osteosarcoma of the extremities
P. PICCI*. G. BACCI*, S. FERRARI*, A. BRACH DEL PREVER**, A. TIENGHI***. A. MANCINI****. L. SANGIORGI*.P. RUGGIERI* y M. MERCURI* * Centro de tumores óseos, Instituto Ortopédico Rizzoli, Bolonia. Italia.** III Departamento de Pediatría, Universidad de Torino, Italia.*** Departamento de Oncología Médica, Hospital de Rarena, Italia. **** IV Departamento de Pediatría, Universidad de Bolonia, Italia.
Recepción:
06/11/2008
Aceptación:
06/11/2008
Publicación:
06/11/2008
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Resumen (ES)
In the seventies, the introduction of preoperative chemotherapy in the treatment of
osteosarcoma dramatically improved the results in terms of disease-free survival and limb salvage
procedures. This paper reports the experience at the Rizzoli Institute showing the results obtained
with several successively activated protocols. Different prognostic factors, including chemotherapy
induced necrosis, dose/intensity, methotrexate serum concentration are also discussed.
osteosarcoma dramatically improved the results in terms of disease-free survival and limb salvage
procedures. This paper reports the experience at the Rizzoli Institute showing the results obtained
with several successively activated protocols. Different prognostic factors, including chemotherapy
induced necrosis, dose/intensity, methotrexate serum concentration are also discussed.
Palabras clave (ES):
Óseo
Maligno
Tratamiento
Osteosarcoma
Tumor
Resumen (EN)
In the seventies, the introduction of preoperative chemotherapy in the treatment of
osteosarcoma dramatically improved the results in terms of disease-free survival and limb salvage
procedures. This paper reports the experience at the Rizzoli Institute showing the results obtained
with several successively activated protocols. Different prognostic factors, including chemotherapy
induced necrosis, dose/intensity, methotrexate serum concentration are also discussed.
osteosarcoma dramatically improved the results in terms of disease-free survival and limb salvage
procedures. This paper reports the experience at the Rizzoli Institute showing the results obtained
with several successively activated protocols. Different prognostic factors, including chemotherapy
induced necrosis, dose/intensity, methotrexate serum concentration are also discussed.
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