30-176
Técnicas especiales en el diagnóstico de tumores óseos
Sophisticated techniques for the diagnosis of bone tumors
F. J. MARTÍNEZ TELLO Departamento de Anatomía Patológica. Hospital Universitario «12 de Octubre». Madrid.
Recepción:
06/11/2008
Aceptación:
06/11/2008
Publicación:
06/11/2008
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54
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Resumen (ES)
In terms of diagnosis and prognosis, the present value of different sophisticated
techniques applied for the patologist on bone tumors is reviewed. Histochemically, alkaline phosphatase
and PAS techniques are both very important for the diagnosis of osteosarcoma and
Ewing's sarcoma respectively. The value of electronic microscopy and immunohistochemistry for
diagnosis of round small cells tumors (Ewing's sarcoma, neuroectodermic tumors, primary bone
lymphoma and metastatic neuroblastoma) and fusocellular sarcomas (fibrosarcoma, leiomyosarcoma
of bone and synovial sarcoma) isdiscussed. The differential diagnosis of chondrosarcoma,
chordoma and metastatic mucosecretor carcinoma at the spine by using immunohistochemistry is
reviewed. The aplication of cytology is very limited and only useful in the hands of patologist expert
in bone tumors. Recent studies on cellular ploidy using the techniques of flow and static cytometry
have shown prognostic value in certain tumors such as chondrosarcoma. The future
seems to be cytogenetics as have been demostrated already for Ewing sarcoma.
techniques applied for the patologist on bone tumors is reviewed. Histochemically, alkaline phosphatase
and PAS techniques are both very important for the diagnosis of osteosarcoma and
Ewing's sarcoma respectively. The value of electronic microscopy and immunohistochemistry for
diagnosis of round small cells tumors (Ewing's sarcoma, neuroectodermic tumors, primary bone
lymphoma and metastatic neuroblastoma) and fusocellular sarcomas (fibrosarcoma, leiomyosarcoma
of bone and synovial sarcoma) isdiscussed. The differential diagnosis of chondrosarcoma,
chordoma and metastatic mucosecretor carcinoma at the spine by using immunohistochemistry is
reviewed. The aplication of cytology is very limited and only useful in the hands of patologist expert
in bone tumors. Recent studies on cellular ploidy using the techniques of flow and static cytometry
have shown prognostic value in certain tumors such as chondrosarcoma. The future
seems to be cytogenetics as have been demostrated already for Ewing sarcoma.
Palabras clave (ES):
Histoquímia
Histología
Diagnóstico
Tumores
Óseo
Resumen (EN)
In terms of diagnosis and prognosis, the present value of different sophisticated
techniques applied for the patologist on bone tumors is reviewed. Histochemically, alkaline phosphatase
and PAS techniques are both very important for the diagnosis of osteosarcoma and
Ewing's sarcoma respectively. The value of electronic microscopy and immunohistochemistry for
diagnosis of round small cells tumors (Ewing's sarcoma, neuroectodermic tumors, primary bone
lymphoma and metastatic neuroblastoma) and fusocellular sarcomas (fibrosarcoma, leiomyosarcoma
of bone and synovial sarcoma) isdiscussed. The differential diagnosis of chondrosarcoma,
chordoma and metastatic mucosecretor carcinoma at the spine by using immunohistochemistry is
reviewed. The aplication of cytology is very limited and only useful in the hands of patologist expert
in bone tumors. Recent studies on cellular ploidy using the techniques of flow and static cytometry
have shown prognostic value in certain tumors such as chondrosarcoma. The future
seems to be cytogenetics as have been demostrated already for Ewing sarcoma.
techniques applied for the patologist on bone tumors is reviewed. Histochemically, alkaline phosphatase
and PAS techniques are both very important for the diagnosis of osteosarcoma and
Ewing's sarcoma respectively. The value of electronic microscopy and immunohistochemistry for
diagnosis of round small cells tumors (Ewing's sarcoma, neuroectodermic tumors, primary bone
lymphoma and metastatic neuroblastoma) and fusocellular sarcomas (fibrosarcoma, leiomyosarcoma
of bone and synovial sarcoma) isdiscussed. The differential diagnosis of chondrosarcoma,
chordoma and metastatic mucosecretor carcinoma at the spine by using immunohistochemistry is
reviewed. The aplication of cytology is very limited and only useful in the hands of patologist expert
in bone tumors. Recent studies on cellular ploidy using the techniques of flow and static cytometry
have shown prognostic value in certain tumors such as chondrosarcoma. The future
seems to be cytogenetics as have been demostrated already for Ewing sarcoma.
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