37-211
Estudio experimental en conejos de un nuevo vidrio bioactivo en la reconstrucción de defectos óseos
Bone defect healing by using a new bioactive glass. An experimental study in rabbits.
R. GARRIDO LAHIGUERA (1), J. GIL ALBAROVA (2), R. GIL ALBAROVA (3), A.L. BUENO LOZANO, A.J. SALINAS SÁNCHEZ (5), M. MELGOSA GIL (1), M. VALLET REGÍ (5) (1) UNIDAD MIXTA DE INVESTIGACIÓN. UNIVERSIDAD DE ZARAGOZA. (2) SERVICIO DE CIRUGÍA ORTOPÉDICA Y TRAUMATOLOGÍA. HOSPITAL UNIVERSITARIO MIGUEL SERVET, ZARAGOZA. (3) SERVICIO DE CIRUGÍA ORTOPÉDICA Y TRAUMATOLOGÍA. HOSPITAL CLÍNICO UNIVERSITARIO. DEPARTAMENTO DE CIRUGÍA, FACULTAD DE MEDICINA. UNIVERSIDAD DE VALENCIA. (4) SERVICIO DE CIRUGÍA ORTOPÉDICA Y TRAUMATOLOGÍA. HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA. ZARAGOZA. (5) DPTO. DE QUÍMICA INORGÁNICA Y BIOINORGÁNICA. FACULTAD DE FARMACIA. UNIVERSIDAD COMPLUTENSE. MADRID.
Recepción:
16/09/2008
Aceptación:
16/09/2008
Publicación:
16/09/2008
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Resumen (ES)
Objective: To evaluate the usefulness of a new bioactive
glass in bone defect healing in rabbits. Material & Methods:
32 New Zealand rabbits were randomly distributed in two groups
of 16: mature and immature respectively. In all of them, a bone
defect was performed in the lateral surface of femoral distal
epiphysis. A glass bioactive implant was placed in the bone
defect of 8 animals in each group. The others served as control.
In the immature rabbits, bone defect results as a Type VI physeal
injury of Rang. Follow-up was 4 months. A standardised radiographic
study was monthly performed, and after sacrifice, a histological
and morphometric study on the femora was done.
Results: All the animals survived the follow-up. No axial deviations
of distal femoral growth were observed in immature rabbits.
The tested glass showed an excellent osteointegration in all the
animals, with osteoconduction evidence over its surface, accompanying
degradation and resorption phenomena, but without
deformities or break. Bone healing over the tested bioactive glass
was higher in immature rabbits than in mature animals. The control
animals showed a poor bone defect healing, with variations
among individuals. Conclusion: The in vivo behaviour of tested
bioactive glass suggests its use as possible bone substitute for
cavities filling, implant surfaces, and as drugs vehicle. In growth
plate surgery, it should be use as interposition material after
physeal bone bridges resection.
glass in bone defect healing in rabbits. Material & Methods:
32 New Zealand rabbits were randomly distributed in two groups
of 16: mature and immature respectively. In all of them, a bone
defect was performed in the lateral surface of femoral distal
epiphysis. A glass bioactive implant was placed in the bone
defect of 8 animals in each group. The others served as control.
In the immature rabbits, bone defect results as a Type VI physeal
injury of Rang. Follow-up was 4 months. A standardised radiographic
study was monthly performed, and after sacrifice, a histological
and morphometric study on the femora was done.
Results: All the animals survived the follow-up. No axial deviations
of distal femoral growth were observed in immature rabbits.
The tested glass showed an excellent osteointegration in all the
animals, with osteoconduction evidence over its surface, accompanying
degradation and resorption phenomena, but without
deformities or break. Bone healing over the tested bioactive glass
was higher in immature rabbits than in mature animals. The control
animals showed a poor bone defect healing, with variations
among individuals. Conclusion: The in vivo behaviour of tested
bioactive glass suggests its use as possible bone substitute for
cavities filling, implant surfaces, and as drugs vehicle. In growth
plate surgery, it should be use as interposition material after
physeal bone bridges resection.
Palabras clave (ES):
Biomaterial
Conejo
Estudio
experimental
Óseo
Defecto
Biovidrio
Vidrio
Bioactivo
Resumen (EN)
Objective: To evaluate the usefulness of a new bioactive
glass in bone defect healing in rabbits. Material & Methods:
32 New Zealand rabbits were randomly distributed in two groups
of 16: mature and immature respectively. In all of them, a bone
defect was performed in the lateral surface of femoral distal
epiphysis. A glass bioactive implant was placed in the bone
defect of 8 animals in each group. The others served as control.
In the immature rabbits, bone defect results as a Type VI physeal
injury of Rang. Follow-up was 4 months. A standardised radiographic
study was monthly performed, and after sacrifice, a histological
and morphometric study on the femora was done.
Results: All the animals survived the follow-up. No axial deviations
of distal femoral growth were observed in immature rabbits.
The tested glass showed an excellent osteointegration in all the
animals, with osteoconduction evidence over its surface, accompanying
degradation and resorption phenomena, but without
deformities or break. Bone healing over the tested bioactive glass
was higher in immature rabbits than in mature animals. The control
animals showed a poor bone defect healing, with variations
among individuals. Conclusion: The in vivo behaviour of tested
bioactive glass suggests its use as possible bone substitute for
cavities filling, implant surfaces, and as drugs vehicle. In growth
plate surgery, it should be use as interposition material after
physeal bone bridges resection.
glass in bone defect healing in rabbits. Material & Methods:
32 New Zealand rabbits were randomly distributed in two groups
of 16: mature and immature respectively. In all of them, a bone
defect was performed in the lateral surface of femoral distal
epiphysis. A glass bioactive implant was placed in the bone
defect of 8 animals in each group. The others served as control.
In the immature rabbits, bone defect results as a Type VI physeal
injury of Rang. Follow-up was 4 months. A standardised radiographic
study was monthly performed, and after sacrifice, a histological
and morphometric study on the femora was done.
Results: All the animals survived the follow-up. No axial deviations
of distal femoral growth were observed in immature rabbits.
The tested glass showed an excellent osteointegration in all the
animals, with osteoconduction evidence over its surface, accompanying
degradation and resorption phenomena, but without
deformities or break. Bone healing over the tested bioactive glass
was higher in immature rabbits than in mature animals. The control
animals showed a poor bone defect healing, with variations
among individuals. Conclusion: The in vivo behaviour of tested
bioactive glass suggests its use as possible bone substitute for
cavities filling, implant surfaces, and as drugs vehicle. In growth
plate surgery, it should be use as interposition material after
physeal bone bridges resection.
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