37-209
Alendronato a dosis bajas en el tratamiento de la enfermedad de paget ósea
A half-dose of alendronate in the treatment of paget's disease of bone
M.F. MINGUEZ*. F. ARGUELLES*, G. RUIZ**, A. SILVESTRE*. R. CEBRIAN***, F. GOMAR SANCHO*. *SERVICIO DE CIRUGÍA ORTOPÉDICA Y TRAUMATOLOGÍA. **SERVICI0 DE MEDICINA NUCLEAR. HOSPITAL CLÍNICO UNIVERSIATARIO DE VALENCIA. ***DEPARTAMENTO DE BIOFÍSICA. FACULTAD DE MEDICINA DE VALENCIA
Recepción:
16/09/2008
Aceptación:
16/09/2008
Publicación:
16/09/2008
Métricas
80
Visualizaciones
Compartir
Compartir
Resumen (ES)
Purpose: To reduce the upper gastrointestinal discomfort,
nausea or oesophageal ulceration as side effects
using a half-dose of alendronate as antipagetic treatment.
Methods: 15 patients with Paget's disease of bone (6 with monostotic
disease and 9 with poliostotic disease) received 20
mg alendronate daily for 6 months. The efficacy was determined
from measurements of biochemical indices of bone turnover.
Results: The mean hydroxiproline excretion decreased
by 66±5% and serum alkaline phosphatase by 51±5%. This decrease
was sufficient to normalize the biochemical indices of
bone turnover in all patients with monostotic disease. No patients
showed gastric and oesophageal disturbances. Conclusions:
The half-dose alendronate therapy avoid side effects
and may be useful for the treatment of Paget's disease, especially
in monostotic cases.
nausea or oesophageal ulceration as side effects
using a half-dose of alendronate as antipagetic treatment.
Methods: 15 patients with Paget's disease of bone (6 with monostotic
disease and 9 with poliostotic disease) received 20
mg alendronate daily for 6 months. The efficacy was determined
from measurements of biochemical indices of bone turnover.
Results: The mean hydroxiproline excretion decreased
by 66±5% and serum alkaline phosphatase by 51±5%. This decrease
was sufficient to normalize the biochemical indices of
bone turnover in all patients with monostotic disease. No patients
showed gastric and oesophageal disturbances. Conclusions:
The half-dose alendronate therapy avoid side effects
and may be useful for the treatment of Paget's disease, especially
in monostotic cases.
Palabras clave (ES):
Bifosfonato
Paget
Enfermedad
Tratamiento
Alendronato
Difosfonato
Resumen (EN)
Purpose: To reduce the upper gastrointestinal discomfort,
nausea or oesophageal ulceration as side effects
using a half-dose of alendronate as antipagetic treatment.
Methods: 15 patients with Paget's disease of bone (6 with monostotic
disease and 9 with poliostotic disease) received 20
mg alendronate daily for 6 months. The efficacy was determined
from measurements of biochemical indices of bone turnover.
Results: The mean hydroxiproline excretion decreased
by 66±5% and serum alkaline phosphatase by 51±5%. This decrease
was sufficient to normalize the biochemical indices of
bone turnover in all patients with monostotic disease. No patients
showed gastric and oesophageal disturbances. Conclusions:
The half-dose alendronate therapy avoid side effects
and may be useful for the treatment of Paget's disease, especially
in monostotic cases.
nausea or oesophageal ulceration as side effects
using a half-dose of alendronate as antipagetic treatment.
Methods: 15 patients with Paget's disease of bone (6 with monostotic
disease and 9 with poliostotic disease) received 20
mg alendronate daily for 6 months. The efficacy was determined
from measurements of biochemical indices of bone turnover.
Results: The mean hydroxiproline excretion decreased
by 66±5% and serum alkaline phosphatase by 51±5%. This decrease
was sufficient to normalize the biochemical indices of
bone turnover in all patients with monostotic disease. No patients
showed gastric and oesophageal disturbances. Conclusions:
The half-dose alendronate therapy avoid side effects
and may be useful for the treatment of Paget's disease, especially
in monostotic cases.
Explorar
Artículos
Volúmenes
Sobre la revista
Más leídos
Surgiceloma como complicación de tenodesis extraarticular de Lemaire modificada asociada a ligamentoplastia del cruzado anterior
Revista Española de Cirugía Osteoarticular
Uso de placa puente dorsal: una alternativa en fracturas de muñeca catastróficas
Revista Española de Cirugía Osteoarticular
No todo es "cut-out": reclasificación de las complicaciones mecánicas del tornillo cefálico del clavo intramedular.
Revista Española de Cirugía Osteoarticular
Solución límite para recambio de prótesis total de cadera con cotilo osteointegrado: presentación de casos
Revista Española de Cirugía Osteoarticular
Radioterapia a bajas dosis en artrosis: ¿una opción terapéutica real o un efecto placebo sofisticado?
Revista Española de Cirugía Osteoarticular