57-292
Inyección intraarticular única de ácido hialurónico en la gonartrosis sintomática: estudio comparativo de la eficacia de dos presentaciones y cambio de protocolo.
Single intra-articular injection of hyaluronic acid in symptomatic gonarthrosis: comparative study of the efficacy of two presentations and change of protocol.
GARCÍA-BRAVO A, PÉREZ-AGUIAR C, DÍAZ-GUTIÉRREZ M, RIVERO M, MATEO-MORATINOS C, BRAVO-MORENO L. HERNÁNDEZ I. SERVICIO DE MEDICINA FÍSICA Y REHABILITACIÓN. HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA. SANTA CRUZ DE TENERIFE
Recepción:
22/12/2022
Aceptación:
22/12/2022
Publicación:
22/12/2022
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Resumen (ES)
Vicosupplementation with hyaluronic acid in knee osteoarthritis has proven to be a safe and effective
treatment. Its effectiveness is maintained for at least 6 months. Few studies have compared the efficacy of two single
injection products at 12 months. Objective: To evaluate the efficacy results in patients infiltrated with two single injection
hyaluronic acid : Hyalone® (H) and Adant One® (A), at 12 months. Material and methods: A retrospective observational
study has been designed on a cohort of patients with knee osteoarthritis. They were treated by intra-articular knee
viscosupplementation with two types of single injection hyaluronic acid. Its efficacy was evaluated according to the
WOMAC scale and the VAS at 6 and 12 months. Results: 86 patients were treated with single doses of A and 67 with H. A
significant improvement was found in the WOMAC assessment at 6 months with A (p = 0.035), while at 12 months the
result no longer showed statistical significance (p = 0.184). With H at 12 months the improvement in the WOMAC values
continued to be favorable (p = 0.039). Regarding pain control, an improvement in the VAS was observed, which was
significant only in the case of H at 12 months (p = 0.020). Conclusions: A single H injection at 12 months was more
effective for pain control and improved functionality in patients with knee osteoarthritis compared to A. It is possible to
make viscosupplementation protocols for knee osteoarthritis with hyaluronic acid at annual intervals using H.
treatment. Its effectiveness is maintained for at least 6 months. Few studies have compared the efficacy of two single
injection products at 12 months. Objective: To evaluate the efficacy results in patients infiltrated with two single injection
hyaluronic acid : Hyalone® (H) and Adant One® (A), at 12 months. Material and methods: A retrospective observational
study has been designed on a cohort of patients with knee osteoarthritis. They were treated by intra-articular knee
viscosupplementation with two types of single injection hyaluronic acid. Its efficacy was evaluated according to the
WOMAC scale and the VAS at 6 and 12 months. Results: 86 patients were treated with single doses of A and 67 with H. A
significant improvement was found in the WOMAC assessment at 6 months with A (p = 0.035), while at 12 months the
result no longer showed statistical significance (p = 0.184). With H at 12 months the improvement in the WOMAC values
continued to be favorable (p = 0.039). Regarding pain control, an improvement in the VAS was observed, which was
significant only in the case of H at 12 months (p = 0.020). Conclusions: A single H injection at 12 months was more
effective for pain control and improved functionality in patients with knee osteoarthritis compared to A. It is possible to
make viscosupplementation protocols for knee osteoarthritis with hyaluronic acid at annual intervals using H.
Palabras clave (ES):
Gonartrosis
Artrosis
Hialurónico
Ácido
Resumen (EN)
Vicosupplementation with hyaluronic acid in knee osteoarthritis has proven to be a safe and effective
treatment. Its effectiveness is maintained for at least 6 months. Few studies have compared the efficacy of two single
injection products at 12 months. Objective: To evaluate the efficacy results in patients infiltrated with two single injection
hyaluronic acid : Hyalone® (H) and Adant One® (A), at 12 months. Material and methods: A retrospective observational
study has been designed on a cohort of patients with knee osteoarthritis. They were treated by intra-articular knee
viscosupplementation with two types of single injection hyaluronic acid. Its efficacy was evaluated according to the
WOMAC scale and the VAS at 6 and 12 months. Results: 86 patients were treated with single doses of A and 67 with H. A
significant improvement was found in the WOMAC assessment at 6 months with A (p = 0.035), while at 12 months the
result no longer showed statistical significance (p = 0.184). With H at 12 months the improvement in the WOMAC values
continued to be favorable (p = 0.039). Regarding pain control, an improvement in the VAS was observed, which was
significant only in the case of H at 12 months (p = 0.020). Conclusions: A single H injection at 12 months was more
effective for pain control and improved functionality in patients with knee osteoarthritis compared to A. It is possible to
make viscosupplementation protocols for knee osteoarthritis with hyaluronic acid at annual intervals using H.
treatment. Its effectiveness is maintained for at least 6 months. Few studies have compared the efficacy of two single
injection products at 12 months. Objective: To evaluate the efficacy results in patients infiltrated with two single injection
hyaluronic acid : Hyalone® (H) and Adant One® (A), at 12 months. Material and methods: A retrospective observational
study has been designed on a cohort of patients with knee osteoarthritis. They were treated by intra-articular knee
viscosupplementation with two types of single injection hyaluronic acid. Its efficacy was evaluated according to the
WOMAC scale and the VAS at 6 and 12 months. Results: 86 patients were treated with single doses of A and 67 with H. A
significant improvement was found in the WOMAC assessment at 6 months with A (p = 0.035), while at 12 months the
result no longer showed statistical significance (p = 0.184). With H at 12 months the improvement in the WOMAC values
continued to be favorable (p = 0.039). Regarding pain control, an improvement in the VAS was observed, which was
significant only in the case of H at 12 months (p = 0.020). Conclusions: A single H injection at 12 months was more
effective for pain control and improved functionality in patients with knee osteoarthritis compared to A. It is possible to
make viscosupplementation protocols for knee osteoarthritis with hyaluronic acid at annual intervals using H.
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