The avascular nature of cartilaginous tissue has historically lead to bad prognosis in osteochondral injuries. One of thepossible treatment options of these injuries is the use of scaffolds, being superior to other options that obtain a fibrouscartilage as a result. We have elaborated PLLA and CHT microspheres as a scaffold for the treatment of osteochondralinjuries carried out in albine New Zealand rabbits. They were distributed into groups with different proportions ofmicrospheres, having also a control group with untreated injuries. Native cartilage of the contralateral knees was alsoanalysed. Samples were evaluated in order to establish the quality of the cartilage obtained (using de macroscopic ICRS,microscopic ICRS II scales and a histomorphometric study).The groups with microspheres obtained a regenerationcartilage with hyaline characteristics, a good cell distribution and regular surface. The control group resulted in a cartilagewith worse organization and an irregular surface.

The avascular nature of cartilaginous tissue has historically lead to bad prognosis in osteochondral injuries. One of thepossible treatment options of these injuries is the use of scaffolds, being superior to other options that obtain a fibrouscartilage as a result. We have elaborated PLLA and CHT microspheres as a scaffold for the treatment of osteochondralinjuries carried out in albine New Zealand rabbits. They were distributed into groups with different proportions ofmicrospheres, having also a control group with untreated injuries. Native cartilage of the contralateral knees was alsoanalysed. Samples were evaluated in order to establish the quality of the cartilage obtained (using de macroscopic ICRS,microscopic ICRS II scales and a histomorphometric study).The groups with microspheres obtained a regenerationcartilage with hyaline characteristics, a good cell distribution and regular surface. The control group resulted in a cartilagewith worse organization and an irregular surface.