Primary bone tumors represent only a small percentage compared to bone metastases. But while neo-adjuvants treatments and reconstruction techniques have improved survival and quality of life of patients with primary bone tumors, primary treatment of bone metastases remains palliative. The goals of treatment for bone metastases are pain relief and maximal functional restoration of the patient, until his death. And of all this, with the help of medical treatment with chemotherapy, bisphosphonates, denosumab, radiotherapy and surgery. At present the recent improvements in our understanding of the biological and molecular mechanisms involved in bone metastasis may lead to better and earlier diagnosis and treatment methods. We try to give a small sample of the current pathophysiology of bone metastases.

Primary bone tumors represent only a small percentage compared to bone metastases. But while neo-adjuvants treatments and reconstruction techniques have improved survival and quality of life of patients with primary bone tumors, primary treatment of bone metastases remains palliative. The goals of treatment for bone metastases are pain relief and maximal functional restoration of the patient, until his death. And of all this, with the help of medical treatment with chemotherapy, bisphosphonates, denosumab, radiotherapy and surgery. At present the recent improvements in our understanding of the biological and molecular mechanisms involved in bone metastasis may lead to better and earlier diagnosis and treatment methods. We try to give a small sample of the current pathophysiology of bone metastases.