The development of plasma prepared in the scientific community has high expectations and a wide dissemination of commercial kits for obtaining platelet-rich plasma (PRP), also known as platelet-rich concentrate (PRC), platelet gel, autologous or plasma rich in growth factors (PRF) and its effect on bone regeneration. The generation of concentrated plasma as working hypothesis is a step forward because the concentration in the number of platelets allows the release of growth factors sustained over time in linear form relationship. There is very little clinical evidence, and a great variability in the preparation of concentrates as well as the amount of platelets and growth factors to provide them as a basis for their use. There is no significant relationship between the number of platelets and the concentration of growth factors which do actually consider whether the PRP and PRF are exactly the same product. We stress the importance of differentiating between the roles played by growth factors "per se", and which performs the platelet ready. The current literature not found any evidence showing the alleged acceleration of healing fractures to the implementation of PRP/PRF. There are reports on its use in muscle, tendon, injuries or their employment in arthroscopic surgery, but it is a preliminary discusses clinical studies. It is therefore necessary to advance in the experimental study that includes the identification and quantification of growth factors in situ in the application of PRP on the regeneration of injuries that allows us to deepen our understanding of the biological behavior of platelet growth factors in bone repair.

The development of plasma prepared in the scientific community has high expectations and a wide dissemination of commercial kits for obtaining platelet-rich plasma (PRP), also known as platelet-rich concentrate (PRC), platelet gel, autologous or plasma rich in growth factors (PRF) and its effect on bone regeneration. The generation of concentrated plasma as working hypothesis is a step forward because the concentration in the number of platelets allows the release of growth factors sustained over time in linear form relationship. There is very little clinical evidence, and a great variability in the preparation of concentrates as well as the amount of platelets and growth factors to provide them as a basis for their use. There is no significant relationship between the number of platelets and the concentration of growth factors which do actually consider whether the PRP and PRF are exactly the same product. We stress the importance of differentiating between the roles played by growth factors "per se", and which performs the platelet ready. The current literature not found any evidence showing the alleged acceleration of healing fractures to the implementation of PRP/PRF. There are reports on its use in muscle, tendon, injuries or their employment in arthroscopic surgery, but it is a preliminary discusses clinical studies. It is therefore necessary to advance in the experimental study that includes the identification and quantification of growth factors in situ in the application of PRP on the regeneration of injuries that allows us to deepen our understanding of the biological behavior of platelet growth factors in bone repair.