34-200
Respuesta de hipersensibilidad retardada en pacientes candidatos a artroplastia de cadera.
The delayed hypersensitivity response in patients candidates to hip arthroplasty.
F. GARCIA-ALVAREZ GARCIA , R. DE MIGUEL OLMEDA, J. C. SALINAS PAYER, F. SERAL IÑIGO SERVICIO DE CIRUGÍA ORTOPÉDICA Y TRAUMATOLOGÍA. DEPARTAMENTO DE CIRUGÍA. HOSPITAL CLÍNICO UNIVERSITARIO "LOZANO BLESA". ZARAGOZA
Recepción:
15/09/2008
Aceptación:
15/09/2008
Publicación:
15/09/2008
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Resumen (ES)
One hundred candidates for hip arthroplasty were
chosen at random (47 Garden IV femoral neck fractures, and 53
osteoarthrosis). Before surgery, serum albumin, total proteins
and hemoglobin were determined in peripheral blood. All
patients were skin tested with seven memory antigens
(Multitest®, Mérieux) in order to measure the delayed hypersensitivity
response. The diameter of the resulting induration
was measured 48 hours after injection. Patients were classified
as reactive if they responded to two or more antigens, or anergic
if they responded to one antigen or showed no response.
Reactive patients supposed 61% of total, and anergic patients
were 12,5 years older (p<0.001). Levels of hemoglobin
(p<0.001), total proteins (p<0.05) and albumin (p<0.0001)
were higher in reactive patients. Anergy was more frequent in
women (29/57) than in men (10/43; p<0.001), and in fractures
(31/47) than in osteoarthrosis (8/53) (p<0.001). No association
between the variables studied and postoperative infection was
found. These differences show immunologic alterations.
However, they have no prognostic value for postoperative infection
in hip arthroplasty patients.
chosen at random (47 Garden IV femoral neck fractures, and 53
osteoarthrosis). Before surgery, serum albumin, total proteins
and hemoglobin were determined in peripheral blood. All
patients were skin tested with seven memory antigens
(Multitest®, Mérieux) in order to measure the delayed hypersensitivity
response. The diameter of the resulting induration
was measured 48 hours after injection. Patients were classified
as reactive if they responded to two or more antigens, or anergic
if they responded to one antigen or showed no response.
Reactive patients supposed 61% of total, and anergic patients
were 12,5 years older (p<0.001). Levels of hemoglobin
(p<0.001), total proteins (p<0.05) and albumin (p<0.0001)
were higher in reactive patients. Anergy was more frequent in
women (29/57) than in men (10/43; p<0.001), and in fractures
(31/47) than in osteoarthrosis (8/53) (p<0.001). No association
between the variables studied and postoperative infection was
found. These differences show immunologic alterations.
However, they have no prognostic value for postoperative infection
in hip arthroplasty patients.
Palabras clave (ES):
Prótesis
Cuello
Fémur
Femoral
Artrosis
Coxartrosis
Subcapital
Fractura
Cadera
Artroplastia
retardada
Hipersensibilidad
Resumen (EN)
One hundred candidates for hip arthroplasty were
chosen at random (47 Garden IV femoral neck fractures, and 53
osteoarthrosis). Before surgery, serum albumin, total proteins
and hemoglobin were determined in peripheral blood. All
patients were skin tested with seven memory antigens
(Multitest®, Mérieux) in order to measure the delayed hypersensitivity
response. The diameter of the resulting induration
was measured 48 hours after injection. Patients were classified
as reactive if they responded to two or more antigens, or anergic
if they responded to one antigen or showed no response.
Reactive patients supposed 61% of total, and anergic patients
were 12,5 years older (p<0.001). Levels of hemoglobin
(p<0.001), total proteins (p<0.05) and albumin (p<0.0001)
were higher in reactive patients. Anergy was more frequent in
women (29/57) than in men (10/43; p<0.001), and in fractures
(31/47) than in osteoarthrosis (8/53) (p<0.001). No association
between the variables studied and postoperative infection was
found. These differences show immunologic alterations.
However, they have no prognostic value for postoperative infection
in hip arthroplasty patients.
chosen at random (47 Garden IV femoral neck fractures, and 53
osteoarthrosis). Before surgery, serum albumin, total proteins
and hemoglobin were determined in peripheral blood. All
patients were skin tested with seven memory antigens
(Multitest®, Mérieux) in order to measure the delayed hypersensitivity
response. The diameter of the resulting induration
was measured 48 hours after injection. Patients were classified
as reactive if they responded to two or more antigens, or anergic
if they responded to one antigen or showed no response.
Reactive patients supposed 61% of total, and anergic patients
were 12,5 years older (p<0.001). Levels of hemoglobin
(p<0.001), total proteins (p<0.05) and albumin (p<0.0001)
were higher in reactive patients. Anergy was more frequent in
women (29/57) than in men (10/43; p<0.001), and in fractures
(31/47) than in osteoarthrosis (8/53) (p<0.001). No association
between the variables studied and postoperative infection was
found. These differences show immunologic alterations.
However, they have no prognostic value for postoperative infection
in hip arthroplasty patients.
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