34-199
Análisis a largo plazo del cartílago producido por injertos libres de periostio tibial en lesiones articulares del cóndilo femoral del conejo.
Long-term analysis of articular cartilage formation induced by tibial periostium free grafts in chondral defects of the medial femoral condyle in the rabbits
L. GARCÍA PAÍNO, A. CARRANZA BENCANO, J.R. ARMAS PADRÓN FACULTAD DE MEDICINA. HOSPITAL UNIVERSITARIO "VIRGEN DEL ROCÍO". UNIVERSIDAD DE SEVILLA.
Recepción:
15/09/2008
Aceptación:
15/09/2008
Publicación:
15/09/2008
Métricas
53
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Resumen (ES)
Purpose of the study: To analyze the healing capacity
of articular cartilage lesions treated with periostium free grafts.
Material and Methods: 36 New Zealand rabbits, 4 - 6 weeks old
were used. A chondral defect was created in the medial femoral
condyle and a free graft of tibial periostium filling the defect was
fixed with Tissucol ® in 18 animals. The other 18 rabbits were
used as controls. The specimens for laboratory study were harvested
at 8, 12 and 24 weeks. Evaluation included macroscopic,
histologic and histochemical results. Mann-Whitney test was
used for statistical analysis. Results: Spontaneous evolution of
the lesion did not lead to complete repair in any case. The periosteum
free implant provided complete repair of cartilage lesions
and restoration of the articular surface that was statistically significant.
Conclusions: This study confirms, in the rabbit, the scarce
spontaneous repair of articular cartilage and the chondrogenic
potential of tibial periosteum free implants, with long term maintenance
of the macroscopic, histologic and histochemical characteristics
of neocartilage. The potential for its use as an alternative
method in repair of circumscribed osteochondral lesions in
young patients is discussed.
of articular cartilage lesions treated with periostium free grafts.
Material and Methods: 36 New Zealand rabbits, 4 - 6 weeks old
were used. A chondral defect was created in the medial femoral
condyle and a free graft of tibial periostium filling the defect was
fixed with Tissucol ® in 18 animals. The other 18 rabbits were
used as controls. The specimens for laboratory study were harvested
at 8, 12 and 24 weeks. Evaluation included macroscopic,
histologic and histochemical results. Mann-Whitney test was
used for statistical analysis. Results: Spontaneous evolution of
the lesion did not lead to complete repair in any case. The periosteum
free implant provided complete repair of cartilage lesions
and restoration of the articular surface that was statistically significant.
Conclusions: This study confirms, in the rabbit, the scarce
spontaneous repair of articular cartilage and the chondrogenic
potential of tibial periosteum free implants, with long term maintenance
of the macroscopic, histologic and histochemical characteristics
of neocartilage. The potential for its use as an alternative
method in repair of circumscribed osteochondral lesions in
young patients is discussed.
Palabras clave (ES):
Reparación
Lesión
Reconstrucción
Articular
Injerto
Periostio
Tibia
Cóndilo
Femoral
Conejo
Estudio
Experimental
Tibial
Fémur
Cartílago
Resumen (EN)
Purpose of the study: To analyze the healing capacity
of articular cartilage lesions treated with periostium free grafts.
Material and Methods: 36 New Zealand rabbits, 4 - 6 weeks old
were used. A chondral defect was created in the medial femoral
condyle and a free graft of tibial periostium filling the defect was
fixed with Tissucol ® in 18 animals. The other 18 rabbits were
used as controls. The specimens for laboratory study were harvested
at 8, 12 and 24 weeks. Evaluation included macroscopic,
histologic and histochemical results. Mann-Whitney test was
used for statistical analysis. Results: Spontaneous evolution of
the lesion did not lead to complete repair in any case. The periosteum
free implant provided complete repair of cartilage lesions
and restoration of the articular surface that was statistically significant.
Conclusions: This study confirms, in the rabbit, the scarce
spontaneous repair of articular cartilage and the chondrogenic
potential of tibial periosteum free implants, with long term maintenance
of the macroscopic, histologic and histochemical characteristics
of neocartilage. The potential for its use as an alternative
method in repair of circumscribed osteochondral lesions in
young patients is discussed.
of articular cartilage lesions treated with periostium free grafts.
Material and Methods: 36 New Zealand rabbits, 4 - 6 weeks old
were used. A chondral defect was created in the medial femoral
condyle and a free graft of tibial periostium filling the defect was
fixed with Tissucol ® in 18 animals. The other 18 rabbits were
used as controls. The specimens for laboratory study were harvested
at 8, 12 and 24 weeks. Evaluation included macroscopic,
histologic and histochemical results. Mann-Whitney test was
used for statistical analysis. Results: Spontaneous evolution of
the lesion did not lead to complete repair in any case. The periosteum
free implant provided complete repair of cartilage lesions
and restoration of the articular surface that was statistically significant.
Conclusions: This study confirms, in the rabbit, the scarce
spontaneous repair of articular cartilage and the chondrogenic
potential of tibial periosteum free implants, with long term maintenance
of the macroscopic, histologic and histochemical characteristics
of neocartilage. The potential for its use as an alternative
method in repair of circumscribed osteochondral lesions in
young patients is discussed.
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