The case of an alveolar soft tissue sarcoma located at the proximal left thighof a 32-year-old woman is reported. The tumor had been growing for 5 years. After radiologicaland complementary studies with CT-scan and MRI, the needle-aspiration biopsy first and thenthe peroperative biopsy were found to be negative regarding malignancy. The histopathologicanalysis of the resected tissue ( 5 x 7 x 6 cm) revealed a low malignant neoplasia of alveolar patternformed by cells with a wide vacuolated cytoplasm exhibiting PAS + inclusions. Immunohistochemicalstudies showed slight positive stain against actin, desmin and S-100 protein.After wide tumor resection, the patient was treated with sistemic chemotherapy and local radiationtherapy. One year after surgery, no local recurrence has been detected. Based on this casereport,the diagnostic and therapeutic approach to soft tissue sarcomas is here reviewed.

The case of an alveolar soft tissue sarcoma located at the proximal left thighof a 32-year-old woman is reported. The tumor had been growing for 5 years. After radiologicaland complementary studies with CT-scan and MRI, the needle-aspiration biopsy first and thenthe peroperative biopsy were found to be negative regarding malignancy. The histopathologicanalysis of the resected tissue ( 5 x 7 x 6 cm) revealed a low malignant neoplasia of alveolar patternformed by cells with a wide vacuolated cytoplasm exhibiting PAS + inclusions. Immunohistochemicalstudies showed slight positive stain against actin, desmin and S-100 protein.After wide tumor resection, the patient was treated with sistemic chemotherapy and local radiationtherapy. One year after surgery, no local recurrence has been detected. Based on this casereport,the diagnostic and therapeutic approach to soft tissue sarcomas is here reviewed.