40-221
Estudio comparativo entre el Fondaparinux y la Nadroparina en la prevención del tromboembolismo venoso tras artroplastias de rodillas
Comparative study between the Fondaparinux and the Nadroparina in the prevention of the venous thromboembolism after total knee arhtroplasty
R. GAVA (*) D. HERNANDEZ VAQUERO (*) (**) (*) SERVICIO DE CIRUGÍA ORTOPÉDICA Y TRAUMATOLOGÍA. HOSPITAL SAN AGUSTIN, AVILES, ASTURIAS. (**) DEPARTAMENTO DE CIRUGÍA. FACULTAD DE MEDICINA. UNIVERSIDAD DE OVIEDO
Recepción:
15/09/2008
Aceptación:
15/09/2008
Publicación:
15/09/2008
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Resumen (ES)
The fondaparinux is a new type of antithrombotic
drugs, the selective inhibitors anti factor Xa activity. Our study
proposes analyzing the differences between the complications
originated for sodium fondaparinux utilization and a low
molecular weight heparin, the nadroparina, in the prophylaxis
after total knee arthroplasty. A prospective study was made of
40 patients with osteoarthritis of the knee as primary diagnosis
that were operated to implant a total knee replacement. In
20 patients we indicate prophylaxis with fondaparinux and in
others 20 with nadroparina. In any patients we found signs or
compatible symptoms of venous thromboembolism or pulmonary
embolism. We did not observe unusual blood loss in the
wound. Revision surgery was not necessary neither we noted
any type of adverse effects. However when we analyze the
quantities collected in the drains and the quantification of
postoperative immediate haemoglobins and in the three days
control we find differences between both patients groups,
although these differences were not statistically significant.
In the fondaparinux group we observed a big blood loss in the
drains and less levels in the three days control haemoglobin.
drugs, the selective inhibitors anti factor Xa activity. Our study
proposes analyzing the differences between the complications
originated for sodium fondaparinux utilization and a low
molecular weight heparin, the nadroparina, in the prophylaxis
after total knee arthroplasty. A prospective study was made of
40 patients with osteoarthritis of the knee as primary diagnosis
that were operated to implant a total knee replacement. In
20 patients we indicate prophylaxis with fondaparinux and in
others 20 with nadroparina. In any patients we found signs or
compatible symptoms of venous thromboembolism or pulmonary
embolism. We did not observe unusual blood loss in the
wound. Revision surgery was not necessary neither we noted
any type of adverse effects. However when we analyze the
quantities collected in the drains and the quantification of
postoperative immediate haemoglobins and in the three days
control we find differences between both patients groups,
although these differences were not statistically significant.
In the fondaparinux group we observed a big blood loss in the
drains and less levels in the three days control haemoglobin.
Palabras clave (ES):
Fondaparinux
Nadroparina
Profilaxis
Prevención
venosa
Artroplastia
Prótesis
Complicaciones
Embolia
Pulmonar
Tromboprofilaxis
Embolismo
Trombosis
Tromboembolismo
Rodilla
Heparina
Resumen (EN)
The fondaparinux is a new type of antithrombotic
drugs, the selective inhibitors anti factor Xa activity. Our study
proposes analyzing the differences between the complications
originated for sodium fondaparinux utilization and a low
molecular weight heparin, the nadroparina, in the prophylaxis
after total knee arthroplasty. A prospective study was made of
40 patients with osteoarthritis of the knee as primary diagnosis
that were operated to implant a total knee replacement. In
20 patients we indicate prophylaxis with fondaparinux and in
others 20 with nadroparina. In any patients we found signs or
compatible symptoms of venous thromboembolism or pulmonary
embolism. We did not observe unusual blood loss in the
wound. Revision surgery was not necessary neither we noted
any type of adverse effects. However when we analyze the
quantities collected in the drains and the quantification of
postoperative immediate haemoglobins and in the three days
control we find differences between both patients groups,
although these differences were not statistically significant.
In the fondaparinux group we observed a big blood loss in the
drains and less levels in the three days control haemoglobin.
drugs, the selective inhibitors anti factor Xa activity. Our study
proposes analyzing the differences between the complications
originated for sodium fondaparinux utilization and a low
molecular weight heparin, the nadroparina, in the prophylaxis
after total knee arthroplasty. A prospective study was made of
40 patients with osteoarthritis of the knee as primary diagnosis
that were operated to implant a total knee replacement. In
20 patients we indicate prophylaxis with fondaparinux and in
others 20 with nadroparina. In any patients we found signs or
compatible symptoms of venous thromboembolism or pulmonary
embolism. We did not observe unusual blood loss in the
wound. Revision surgery was not necessary neither we noted
any type of adverse effects. However when we analyze the
quantities collected in the drains and the quantification of
postoperative immediate haemoglobins and in the three days
control we find differences between both patients groups,
although these differences were not statistically significant.
In the fondaparinux group we observed a big blood loss in the
drains and less levels in the three days control haemoglobin.
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